Discussion

The Problem: Current in vivo animal models do not accurately represent human physiology. Data suggests that 9 out of 10 drugs that pass animal testing fail during human clinical testing, costing the industry $millions per failed drug candidate. Although traditional in vitro techniques can provide valuable insights, there are limitations to these systems: they only partially replicate normal biological processes, which impacts on the utility and reliability of the resultant data.
The Solution: Quasi Vivo® perfusion systems provide nutrient flow which allows for co-culture and development of 3D structures. When cultured under perfusion flow, we have shown that cell viability, physiology and function are improved. Modelling of the QV500 has demonstrated improved oxygen availability in comparison with other milli- and micro-fluidic systems. Kirkstall is collaborating with many world-class researchers to develop advanced cell culture applications, which are described in this poster.