Discussion

TriTrypDB (http://tritrypdb.org) is a free, online data mining resource that facilitates the discovery of biological relationships from large volumes of data by integrating pre-analyzed omics data with advanced search capabilities, data visualization and analysis tools. TriTrypDB supports over 25 organisms from the Kinetoplastida. These include many species of Leishmania  and Trypanosoma (including multiple strains of T. brucei, T. cruzi, and others) from a variety of hosts, as well as the related genera Leptomonas, Crithidia and Endotrypanum. TriTrypDB integrates a wide range of data including genome sequence and annotation, transcriptomics, proteomics, epigenomics, metabolomics, population resequencing clinical and field isolates, and data that inform host-pathogen interactions. Data are analyzed using standard workflows and an in-house analysis pipeline generates data including domain predictions, orthology profiles and GO term associations. Our unique strategies system offers over 100 structured searches that query the pre-computed data. Individual search results can be combined into strategies that merge evidence from diverse data types and across organisms. Accessible tools enhance the search strategy system and include dynamic data visualization, comparative genome analysis, population genetics tools, and functional or pathway enrichment. Forthcoming features include a private user work-space for primary data analysis, functional analysis tools for result summarization, genome browser and query improvements. This comprehensive resource places the power of bioinformatics with the scientific community supporting hypothesis driven research. Updates include: completely revamped gene pages, alternative transcripts represented in gene pages and strategies, new search categories with a "Find a Search" tool and additional data. To learn more visit our booth during any poster session.