Authors
J Ballester Beltran1; A Dalby1; C Lincetto1; N Foad1; E Turro1; M Tijssen1; T Moreau1; C Ghevaert1;
1 University of Cambridge, UK
Abstract
Forward Programming (FoP) relies on the fact that cell identity is controlled by limited sets of transcription factors (TFs). Exogenous expression of three key haematopoietic TFs (GATA1, TAL1 and FLI1) was previously shown to produce mature megakaryocytes (mat MKs) from induced pluripotent stem cells (Nat Commun. 2016;7:11208). Here we describe how FoP generates a bi-potent progenitor cell (BPP), capable of producing both MKs and erythrocytes (Ery) in permissive cytokine conditions.
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