Abstract

Flow cytometry has always been used in Drug Discovery, however throughput limitations have excluded it from the typical drug screen laboratory. A combination of recent advances in flow cytometry technology and an increasing interest in phenotypic assays has meant that more and more flow cytometers are appearing in drug screening laboratories. Described are some of the specific areas where high throughput flow cytometry has been used, in particular, its application to profiling large compound sets in phenotypic focussed screening campaigns