Abstract

Evotec has a strong expertise in hit identification and can support its partners screening campaigns through multiple platforms including virtual, biochemical, biophysical, cell and phenotypic based screening with high-throughput capabilities. Evotec state-of-the-art platforms cover a large panel of drug discovery activities: reagents production (proteins, assay ready cells, cell line generation), compound management (both Evotec and partners libraries), assay development and miniaturization, high throughput screening using multiple read-out parameters, orthogonal assays, structural biology and medicinal chemistry to ensure the identification of the best chemical matter with the required drug like profiles. We will describe Evotec broad technology capabilities and how Evotec interdisciplinary project teams design the most adequate hit identification campaign ensuring the highest chance of success along with a few case studies.