The inefficiency of the drug discovery process is a widely accepted problem in the pharmaceutical industry. Investment in pharmaceutical R&D continues to increase, while the number of new drugs approved by the US Food and Drug Administration remains low1. Dianthus NT.23PicoDuo from NanoTemper Technologies can improve the molecular interaction screening process for fragment-based and small molecule drug discovery by providing fast, non-stop and highly sensitive screening with a 384-well plate format, no microfluidics, broad sensitivity range and low sample consumption.

Here we show data from single-dose screening (hit ID) of a fragment library with a broad molecular mass and complexity range against the target molecule histone methyltransferase (HMT) G9a, followed by affinity screen of selected hit fragments.