Research and Innovation 2023 – Accelerating future drug discovery

Presentation

29 March

Thursday 30 March

[Schedule with Sessions only]

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

All times shown are GMT —

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

09:00

Registration & Coffee

09:00

09:05

09:10

09:15

09:20

09:25

09:30

Research and Innovation 2023 – Accelerating future drug discovery

Chairs: Roger Clark, Charles River Labs Saleha Patel, AstraZeneca

Conference Welcome and Keynote Introduction
09:30 (5 mins)
Saleha Patel, AstraZeneca Roger Clark, Charles River Labs

New perspective on an age-old question
09:35 (45 mins)
Ken Raj, Altos Labs Cambridge Institute of Science

09:30

09:35

09:40

09:45

09:50

09:55

10:00

10:05

10:10

10:15

10:20

Early Career Professional Impact Award

Chairs: Del Trezise, Sartorius AG

Early Career Professional Impact Award Introduction
10:20 (5 mins)
Del Trezise, Sartorius AG

Early Career Professional Impact Award - Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation
10:25 (15 mins)
Yichao Yu, University College London

10:20

10:25

10:30

10:35

10:40

Refreshment Break

10:40

10:45

10:50

10:55

11:00

11:05

11:10

11:15

Age-Old Challenges, Modern Solutions: The Role of Geroscience in Addressing Age-Related Diseases

Chairs: Lynne Cox, University of Oxford Janet Lord, University of Birmingham

Session Introduction
11:15 (5 mins)
Lynne Cox, University of Oxford Janet Lord, University of Birmingham

Longevity Pharmacology Comes of Age
11:20 (30 mins)
Joao Pedro de Magalhaes, University of Birmingham

Technology Spotlight Partner
11:50 (5 mins)

From Target Engagement to Cellular Effect How to Position CETSA in the Drug Discovery Process
11:55 (15 mins)
Yasmin Andersson — Pelago Bioscience AB

UK SPINE, targeting drug discovery for age-related multimorbidity
12:10 (30 mins)
Graeme Wilkinson, Medicines Discovery Catapult

The rise of AI driven drug discovery

Chairs: Kathryn Giblin, AstraZeneca Garry Pairaudeau, Exscientia

Session Introduction
11:15 (5 mins)
Kathryn Giblin, AstraZeneca Garry Pairaudeau, Exscientia

Accelerating Drug Discovery with Computer Vision
11:20 (30 mins)
Greg Slabaugh, Queen Mary University of London

Technology Spotlight Partner
11:50 (5 mins)

ML Tools in Drug Discovery
11:55 (15 mins)
Thomas Waldmann, WuXi AppTec

Predictive Minisci and P450 Late Stage Functionalization with Transfer Learning
12:10 (30 mins)
Emma King-Smith, University of Cambridge

11:15

11:20

11:25

11:30

11:35

11:40

11:45

11:50

11:55

12:00

12:05

12:10

12:15

12:20

12:25

12:30

12:35

12:40

CoSolve sustainability live pitching event - Novel technologies to enable filter tip reuse or recycl

Chairs: Kelly Gray, Emerging Innovations Unit, AstraZeneca

CoSolve Finalist Presentation - Sustainable technologies to enable filter tip reuse and recycling in research and development
12:40 (10 mins)
Katrina Cornish, The Ohio State University

CoSolve Finalist Presentation - Using filters as new thermal insulation materials
12:50 (10 mins)
Mohamed Ali, King Saud University

CoSolve Finalist Presentation - Filter-remover box to recycle or reuse tips
13:00 (10 mins)
Alberto Portone, TPM, Science & Technology Park for Medicine

12:40

12:45

12:50

12:55

13:00

13:05

13:10

13:15

13:20

Refreshment Break - Poster Session 13.30 - 14.00

13:20

13:25

13:30

13:35

13:40

13:45

13:50

13:55

14:00

14:05

14:10

14:15

14:20

Age-Old Challenges, Modern Solutions: The Role of Geroscience in Addressing Age-Related Diseases

Chairs: Lynne Cox, University of Oxford Janet Lord, University of Birmingham

Oligonucleotide senotherapeutics for the diseases of ageing
14:20 (30 mins)
Lorna Harries, Institute of Biomedical and Clinical Science, Medical School, College of Medicine and Health, Univer

Providing in vivo data on ageing endpoints early in drug discovery
14:50 (30 mins)
David Weinkove, Magnitude Biosciences

Cryo-ET for investigating the role of respiratory chain organisation in health and disease
15:20 (10 mins)
Emma Buzzard, University of Exeter

The rise of AI driven drug discovery

Chairs: Kathryn Giblin, AstraZeneca Garry Pairaudeau, Exscientia

Learning rich molecular representations from quantum mechanics
14:20 (30 mins)
Ward Haddadin, Exscientia

Federated Learning in Drug Discovery
14:50 (30 mins)
Lewis Mervin, AstraZeneca

A novel in silico simulation platform to untangle biological pathway mechanisms in Type 1 Diabetes progression
15:20 (10 mins)
Raminderpal Singh, Incubate.bio

14:20

14:25

14:30

14:35

14:40

14:45

14:50

14:55

15:00

15:05

15:10

15:15

15:20

15:25

15:30

Comfort Break

15:30

15:35

15:40

Age-Old Challenges, Modern Solutions: The Role of Geroscience in Addressing Age-Related Diseases

Chairs: Lynne Cox, University of Oxford Janet Lord, University of Birmingham

Strategies to target senescence
15:40 (30 mins)
Jesus Gil, MRC London Institute of Medical Sciences

Autophagy as a pathway to rejuvenate immune responses
16:10 (30 mins)
Ghada Alsaleh, Oxford University

The rise of AI driven drug discovery

Chairs: Kathryn Giblin, AstraZeneca Garry Pairaudeau, Exscientia

Mapping the Rare Disease Knowledge Graph
15:40 (30 mins)
Daniel O'Donovan, healx

Human-in-the-loop modelling for de novo molecular generation
16:10 (30 mins)
Samuel Kaski, University of Manchester and Aalto University

15:40

15:45

15:50

15:55

16:00

16:05

16:10

16:15

16:20

16:25

16:30

16:35

16:40

16:45

16:50

16:55

17:00

17:05

17:10

17:15

17:20

17:25

17:30

17:35

17:40

17:45

17:50

17:55

18:00

18:05

18:10

18:15

18:20

18:25

18:30

18:35

18:40

18:45

18:50

18:55

19:00