Drug Discovery 2021 After the Storm: Re-connect, Re-invent, Re-imagine

Posters

Saint-Cricq-Riviere
Dr Philippe Saint-Cricq-Riviere
nanoComposix
United States
1Mesoporous silica & PLGA nanoparticles for next-generation drug delivery & targeted therapeutic technologies
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Focke
Mr Lukas Focke
acCELLerate GmbH
Germany
2Patch Ready Cells – Flexible Tools in Cardiotoxicity Testing
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Winn
Dr Kirsty Winn
Medicines Discovery Catapult
3A roadmap for the discovery of therapeutics in healthy ageing
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Bloom
Dr Jon Bloom
Pharmaron UK
4A Novel Method for the Early, Rapid Assessment of Tissue Distribution for New Drug Candidates
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Lai
Ms Wing Yee Lai
University of East Anglia
5Investigation into the roles of protein kinase D (PKD) in CXCL12/CXCR4 signalling in cancer cells
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Vadlamudi
Dr Sree Vadlamudi
Iktos AI
France
6Fragment growth with reaction predictions for hit discovery
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Vadlamudi
Dr Sree Vadlamudi
Iktos AI
France
7Discovery of Novel Inhibitors of PIM-1 Kinase Enabled by Generative AI
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Reynisson
Dr Jóhannes Reynisson
Keele University
8Targeting Mtb isocitrate lyase for the treatment of tuberculosis
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Obergrussberger
Dr Alison Obergrussberger
Nanion Technologies GmbH
Germany
9Reliable identification of cardiac liability in drug discovery using automated patch clamp: Experimental and technical considerations for high throughput recordings of NaV1.5 and hERG
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Qureshi
Dr Omar Qureshi
Celentyx
10A cell-based, SARS-CoV-2 spike protein binding assay reveals differential impact of RBD-targeting antibodies
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Okolo
Dr Chidinma Okolo
Diamond Light Source
11Soft X-ray tomography and structured illumination fluorescence microscopy as integrated high throughput pipelines for drug discovery, production and post-market surveillance
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Stuart
Dr Kate Stuart
PhoreMost Ltd
12PhoreMost: Drugging the Undruggable
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Marella
Dr Saritha Marella
Acharya N.G Ranga Agricultural University
India
13Nanoencapsulated Ellagic acid-inhibitory actions on aldose reductase and α-glucosidase in secondary complications of diabetes
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Lamont
Miss Tamsin Lamont
Collaborative Drug Discovery
14Managing Antibiotics Research Data with CDD Vault, a Drug Discovery Collaborative Platform
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Legros
Dr Celine Legros
Eurofins Discovery
France
15Investigating Potential Therapeutic Targets for the Treatment of Fibrotic Diseases.
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Legros
Dr Celine Legros
Eurofins Discovery
France
16High Throughput Screening cascade to generate highly selective hits for PIM3 kinase
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Chilian
Dr Bruno Chilian
TRI Thinking Research Instruments GmbH
Germany
17Quantifying Cell Morphology With Label-free Imaging and Deep Learning
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Stott
Dr Lisa Stott
Sosei Heptares
18Characterisation of [3H]-HTL45725, a Novel Radioligand for the Orphan Receptor GPR52
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Duncan
Miss Elaine Duncan
Charles River Discovery
19Toxin pharmacology and MoA data against Nav1.X channels: Multi-parameter analysis using Sophion Qube high-throughput automated patch clamp platform
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Trigg
Miss Jasmine Trigg
Sartorius
20Visualization and quantification of phagocytosis using live-cell analysis and advanced flow cytometry
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McBain
Miss Kirsty McBain
Sartorius
21Quantify T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry and Live-Cell Analysis
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Suckling
Dr Lorna Suckling
GlaxoSmithKline
22The Identification of Novel Drug Target Candidates in T cells
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Knight
Dr David Knight
Isogenica
23VHH drug discovery using synthetic libraries
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Pearson
Ms Lesley-Anne Pearson
University of Dundee
24Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7- Methyltransferase Using RapidFire Mass Spectrometry
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Ferhat
Mr Mourad Ferhat
IsoPlexis
United States
25Highly Multiplexed, Single-Cell Functional Profiling of CAR-T Products Enables More Predictive Product Characterization, Cell Manufacturing optimization, and Cellular Biomarkers across Product Types
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Hidalgo de Quintana
Dr Juan Hidalgo de Quintana
Thermo Fisher Scientific
26Multiplexing protein and gene level measurements on a single Luminex platform
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Papamichos
Dr Manolis Papamichos
Universtiy of Liverpool
27Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.
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Slack
Dr Rob Slack
Galecto, Inc.
28Plasma LOXL2 target engagement by GB2064, a high affinity, small-molecule LOXL2 inhibitor, in a phase 1 healthy subject study.
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Slack
Dr Rob Slack
Galecto, Inc.
29Translational pharmacology of GB0139, an inhaled small molecule galectin-3 inhibitor for the treatment of idiopathic pulmonary fibrosis.
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Slack
Dr Rob Slack
Galecto, Inc.
30Determination of the affinity and kinetic rate constants of galectin inhibitors using surface plasmon resonance.
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Patel
Miss Chandni Patel
University of Liverpool
31Determining drug activity against SARS-CoV-2 using lab-generated lentiviral vectors pseudo-typed with the SARS-CoV-2 spike glycoprotein
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Thomas
Mr Bedwyr ab Ion Thomas
The Medicines Discovery Institute, Cardiff University
32Developing Therapies for Prion Diseases
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Lubis
Mr Restuan Lubis
Lead Discovery Center
Germany
33A successful high-throughput screening campaign for new small molecule inhibitors of BLM Helicase
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Nagbou
Mrs Atf Nagbou
Axxam SpA
Italy
34Identifying Ryanodine Receptor Modulators: From High-Throughput Screening to Single Channel Recording
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Tholozan
Dr Frederique Tholozan
Magnitude Biosciences
35Automated Monitoring of C. elegans Movement for Neurodegeneration and Ageing: Tissue and Lifecourse Matter
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Mordue
Dr Ryan Mordue
Aurelia Bioscience Ltd
36CyBio FeliX: Making Simple Western™ Technology … More Simple
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Dodgson
Mrs Kathy Dodgson
Aurelia Bioscience Ltd
37The benefits of real time measurement of cells (black and white or colour) - Utilisation of the Incucyte® SX5 at a CRO
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Peall
Dr Adam Peall
Aurelia Bioscience
38Development of a Robust Screening Cascade to Identify Small Molecule Inhibitors of a DNA Damage Response Protein
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McLaughlan
Mrs Jenny McLaughlan
Aurelia Bioscience
39Alternative Methods to Increase PROTAC Screening Throughput
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Rucka
Dr Marta Rucka
bit.bio
40Reprogramming cell identity: enabling the next generation of human cells
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Chapman
Miss Kerry Chapman
PerkinElmer
41Enhance PROTAC Drug Discovery with a Comprehensive No-Wash Technological Platform: A BTK Case Study
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Dickinson
Ms Paula Dickinson
Nexcelom Bioscience Ltd
United States
42Improved Inter-Instrument Consistency and High Precision for CHO Cell Bioprocessing Using the Cellaca MX High-Throughput Cell Counter
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Webb
Dr Alice Webb
Lifearc
43High throughput protein workflows for antimicrobial drug design
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Clapés
Miss Maria Clapés
SUN bioscience SA
Switzerland
44An automated standardized screening workflow for assessing combination therapies in human pancreatic cancer organoids
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Jewell
Ms Charlotte Jewell
Platelet Services Ltd
45Platelet function testing in drug discovery projects: considerations and challenges
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McCullough
Dr Danielle McCullough
Venomtech Ltd
46Novel GPCR ligands: GPR120 case study
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Hart
Dr Philippa Hart
Medicines Discovery Catapult
47Accumulation of Bioactive lipids in LPS-induced Neuroinflammation models: MSI Biomarkers
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Humphries
Mr Bob Humphries
TherapeutAix
Germany
48Inhalation: The Inspired Choice in the Treatment of Respiratory Disease
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Trim
Mr Steven Trim
Venomtech
49Novel biologics for disrupting programmed cell death receptor PD-1 binding to PD-L1
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Cruz
Mr Andoni Cruz
BBD BioPhenix
United States
50Validation of Zebrafish Embryotoxicity Test (ZET) as a Qualified Alternative Assay For Its Regulatory Use.
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Alkassem
Dr Hasan Alkassem
Biosynth Carbosynth
51X-Shining(TM) Luciferase Product Range
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Lopes Rodrigues
Dr Rosalia Lopes Rodrigues
Nanovery
52Nanorobotic Sensors as a Novel Platform for Nucleic Acid Biomarker Detection in Blood
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Hatty
Dr Claire Hatty
NanoTemper Technologies, Ltd.
53Utilizing isothermal spectral shift detection to quantify challenging biomolecular interactions with Monolith X
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Rackliff
Mr Miles Rackliff
My Customer and me.com
54Key scientists require key technologies or is this vice versa?
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Holiday
Dr Alison Holiday
Domainex
55“Scar-in-a-jar”: in vitro assay for the quantification of key markers of fibrosis
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Wylie
Mr Paul Wylie
Abcam
56Accelerating high-throughput screening using FirePlex -384 multiplexing technology with high-content imaging and laboratory automation
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Wolf
Dr Jana Wolf
Domainex
57Fragment library screening by Grating Coupling Interferometry (GCI) and benefits over Surface Plasmon Resonance (SPR)
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Todeschini
Mrs Léa Todeschini
AlveoliX
Switzerland
58A smart breathing alveolus on chip model: concept and applications
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PONNAPPAN
Dr NISHA PONNAPPAN
Medicines Discovery Catapult
59Investigation of Nuvec Particles for Effective Gene Delivery
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Mckinnon
Mrs Erica Mckinnon
Gilson Scientific ltd
60Automation of a Secondary Drug Screen for ALS Using iPSC-Derived Human Neurons
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Nass Kovacs
Dr Gabriela Nass Kovacs
Genedata AG
Switzerland
61A New Workflow Automating the Data Analysis in Gene Expression Screens Across Assay Formats Produces Consistent Results at Scale and Efficiency
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Miezaniec
Dr Agata Miezaniec
Ardigen
Poland
62Novel Strategy for Identification of Gut Microbiome Biomarkers of Parkinson’s Disease Using Artificial Intelligence Algorithms
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Temple
Mr Jonathan Temple
University of Liverpool
63Evaluation of spheroid and scaffold-based liver cultures for the development of a reliable model for the prediction of drug hepatotoxicity
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Eyres
Dr Michael Eyres
Medicines Discovery Catapult
64Spatial Proteomics and Transcriptomics using GeoMx Digital Spatial Profiling
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Noerenberg
Mrs Astrid Noerenberg
upcyte technologies GmbH
Germany
65Generations of Expanded Primary Cells and Modified Cell Lines for Drug Discovery Screenings
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Platt
Miss Eleanor Platt
Medicine Discovery Catapult
66mRNA biomarkers of ageing in plasma samples
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Killoran
Dr Patrick Killoran
GyreOx
67A chemoenzymatic solution for cell-permeable therapeutic macrocycles
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Barkan
Dr Kerry Barkan
Sosei Heptares
68Dynamic Mass Redistribution (DMR) as a Method to Enable Real-time Investigation of CKR Signalling in Live Human T Cells
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Walter
Mrs Joanne Walter
Fida Biosystems ApS
Denmark
69Flow Induced Dispersion Analysis (FIDA) for size-based characterization of proteins and protein interactions under native conditions
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Hanson
Ms Stacey Hanson
LifeNet Health LifeSciences
United States
70A Novel in Vitro All-Human Tri-Culture Model That Maintains Structural Organization And Key Functions of Primary Hepatocytes Over Several Weeks
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Loo
Mrs Jasmin Loo
Arctoris Ltd
71Implementing fully automated kinase inhibitor characterization using a robotic system
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Williams
Mrs Carol Williams
PerkinElmer
72High Content Compatible Fast Frame Rate Imaging of GPCR mediated Calcium Signaling
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Adams
Miss Candace Adams
LightOx ltd
73Photoreact365: Uniform, directed and reproducible UV light irradiation for photobiological and photochemical applications.
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Hamilton
Miss Amy Hamilton
Levitas Bio
United States
74Rare CRISPR BCL-2 KO Cells Discovered Using Levitation Technology
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Vaitone
Dr Egle Vaitone
LifeArc
75Profiling two-pore domain potassium (K2P) channel gene expression in pain-relevant cells
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Harrison
Dr James Harrison
Aston University
76In vitro efficacy of relebactam versus avibactam against Mycobacterium abscessus complex
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Zernickel
Dr Erika Zernickel
Yokogawa
Germany
77High Content Analysis Portfolio
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Zernickel
Dr Erika Zernickel
Yokogawa
Germany
78High-Content Analysis Portfolio
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Shah
Mr Muji Shah
Promega
79Spectrum Compact CE System –A Personal, Benchtop Capillary Electrophoresis Device
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Nolan
Miss Victoria Nolan
Aston University
80Clinical Significance of Manuka and Medical-Grade Honey for Antibiotic-Resistant Infections: A Systematic Review
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Knowling
Dr Stuart Knowling
Sartorius
81High Productivity and Process Economy in GxP Applications with the Octet® Platform
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Gaffey
Mr Finbar Gaffey
LifeArc
82High throughput quantitative pharmacology: cross platform comparison of ion channel activating compounds for pain
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Taylor
Miss Mae Taylor
LifeArc
83Mixed Reality at LifeArc: Expanding mixed reality technology to augment laboratory-based research
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Braidley
Mr Sam Braidley
Domainex
85Covalent Fragment Screen using QToF analysis
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Bland
Dr Nicholas Bland
Domainex
86Disrupting the Role of Biophysics in Drug Discovery: The NanoTemper Dianthus, A Medium Throughput Biophysical Screening Platform
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Benson
Mr Saheed Benson
LJMU
87A cell-based neuroprotection assay targeting poly (ADP-ribose) polymerase (PARP) reveals oncology-based potency ranking of clinically used PARP inhibitors (PARPi)
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Allenby
Mr Gary Allenby
Aurelia Bioscience
88ISOLIGHT Technology: Cytokines Profiles in Patients with Psoriasis and Psoriatic Arthritis. Determination of Similarities and Differences within Serum from Individual Patients
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Jamard
Miss Melanie Jamard
WuXi AppTec
90Unleashing the Potential of Hit Discovery
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McIntyre
Dr Patrick McIntyre
Aurelia Bioscience
91Higher throughput techniques for PROTAC drug discovery
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Mohamed
Ms Gehad Mohamed
Keele University
92The effect of different levels of BCAA on paclitaxel sensitivity
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Joubert
Mr Jean-Pierre Joubert
CN Bio Innovations Ltd
93Human liver microphysiological system for studying acute and chronic drug-induced liver toxicity in vitro
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Joubert
Mr Jean-Pierre Joubert
CN Bio Innovations Ltd
94Pharmacokinetic profiles revisited in 3D microfluidic tumour models
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Stewart
Dr Mark Stewart
Domainex Ltd
95Domainex: Integrated drug discovery
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Reynolds
Mrs Nicola Reynolds
Flexible Lab Solutions
96Flexible Lab Solutions
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Southan
Dr Christopher Southan
Medicines Discovery Catapult
Sweden
9740 million open chemical structures from patents: treasure trove? junk yard? or both?
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Shea
Dr Kerry Shea
Medicines Discovery Catapult
98Human iPSC Derived Microglia Cell Assays
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Rehman
Dr Samrina Rehman
Medicines Discovery Catapult
99From Data to Knowledge - Informatics at Medicines Discovery Catapult
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Wang
Dr Qiuyu Wang
Manchester Metropolitan University
100Immunomodulatory activities of arabinoxylan on human colon adenocarcinoma cells in vitro
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Burusco-Goni
Dr Kepa Burusco-Goni
Medicines Discovery Catapult
101Drug Repurposing for the Elderly And Multimorbid: Dr-EAM.ai
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