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| Wednesday 24 March |
| Conference Hall | DAY 2 |
| Conference Hall | DAY 2 | ||
| 11:00 | Welcome & Introductions Chairs: Andrew Bassett, Wellcome Sanger Institute Klio Maratou, GlaxoSmithKline Marcello Maresca, AstraZeneca Welcome & Introductions 11:00 (5 mins) Andrew Bassett, Wellcome Sanger Institute Klio Maratou, GlaxoSmithKline Marcello Maresca, AstraZeneca |
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| 11:05 | Target Validation - Sponsored by Iota Sciences Chairs: Klio Maratou, GlaxoSmithKline Examining intrinsic and extrinsic regulation of human brain development using cerebral organoids 11:05 (45 mins) Madeline Lancaster, MRC Laboratory of Molecular Biology, Cambridge |
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| 12:20 | Refreshment Break/Poster Session/Vendor Exhibition | 12:20 | ||
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| 13:20 | Target Validation - Sponsored by Iota Sciences Chairs: Klio Maratou, GlaxoSmithKline Session Chair Welcome 13:20 (5 mins) Klio Maratou, GlaxoSmithKline Therapeutic strategies via genome engineering: new approaches and new challenges 13:25 (20 mins) Prashant Mali, UCSD Deciphering the pathogenicity of cardiac disease-associated genetic variants using human iPSCs and gene editing 13:45 (20 mins) Richard Davis, Leiden University Medical Center |
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| 14:20 | Refreshment Break | 14:20 | ||
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| 14:30 | Target Validation - Sponsored by Iota Sciences Chairs: Klio Maratou, GlaxoSmithKline Cell engineering at the speed of light 14:30 (20 mins) Greg Sienski, AstraZeneca Joint Q&A Session 14:50 (20 mins) Prashant Mali, UCSD Richard Davis, Leiden University Medical Center Greg Sienski, AstraZeneca |
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| 15:25 | Refreshment Break | 15:25 | ||
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| 15:35 | Therapeutics - Sponsored by Iota Sciences Chairs: Marcello Maresca, AstraZeneca Mechanistic Insights into Cytosine and Adenine Base Editors 16:20 (20 mins) Alexis Komor, UCSD |
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| 16:40 | Refreshment Break | 16:40 | ||
| 16:45 | Expanding gene-editing tool delivery and targeting range in human cells 16:45 (20 mins) Manuel Goncalves, LUMC Strategies to improve precision and safety of human cells manipulation 17:05 (20 mins) Claudio Mussolino, University of Freiburg Joint Q&A Session 17:25 (20 mins) Alexis Komor, UCSD Manuel Goncalves, LUMC Claudio Mussolino, University of Freiburg Modulation of DNA repair pathways by HDR-CRISPR promotes seamless genome editing in primary human hematopoietic cells 17:45 (5 mins) Modulation of DNA repair pathways by HDR-CRISPR promotes seamless genome editing in primary human hematopoietic cells 17:45 (5 mins) Antonio Carusillo, Center for Transfusion Medicine and Gene Therapy Homology-directed safe harbour insertion of transgenes encoding full-length dystrophin through high-capacity adenoviral vector delivery of CRISPR-Cas9 nucleases and donor DNA 17:50 (5 mins) What do people think about genetic engineering: a systematic review of post-CRISPR questionnaires 17:55 (5 mins) Joint Q&A Session 18:00 (5 mins) Conference Close & Poster Winner Presentations 18:05 (10 mins) |
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