Ulrich Elling

Ulrich Elling runs an academic research lab at the IMBA in Vienna, Austria. His group is focused on cell identity transitions as well as the development of genetic screening tools like the development of mouse haploid embryonic stem cells as a tool for high throughput genetic. Recent work focused on improvements of CRISPR/Cas9 as a genetic screening tool such as CRISPR-UMI, a single-cell tracing method for CRISPR screening to counteract cellular heterogeneity as well as various editing outcomes as well as CRISPR-Switch, a tight and rapidly inducible control of sgRNA activity. The latest development by the group is a markedly improved score for sgRNA selection called the VBC-score. In response to Covid-19 his group has also developed a high-throughput pipeline for mutational surveillance of the SARS-CoV2 S-gene and is currently sequencing it in 10-15% of all Austrian patients.