| Welcome & Introductions | |||||
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Tue23 Mar11:00am(5 mins)
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Dr Andrew Bassett |
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Dr Marcello Maresca | |
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Dr Klio Maratou | ||||
| Session : Welcome & Introductions | |||||
| Room: Conference Hall | |||||
| Functional Genomics to Guide Cancer Drug Discovery | |||||
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Tue23 Mar11:05am(45 mins)
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Mathew Garnett | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| CRISPR screening to identify new drug targets in complex cell models | |||||
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Tue23 Mar11:50am(30 mins)
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Dr Carlos le Sage | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Session Chair Welcome | |||||
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Tue23 Mar01:20pm(5 mins)
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Dr Andrew Bassett | |||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Using CRISPR/Cas9 screens to study epidermal keratinocyte differentiation and inflammation | |||||
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Tue23 Mar01:25pm(20 mins)
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Dr Christopher Bryant | |||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles | |||||
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Tue23 Mar01:45pm(20 mins)
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Ulrich Elling | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Joint Q&A Session | |||||
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Tue23 Mar02:05pm(20 mins)
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Mathew Garnett |
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Dr Christopher Bryant | |
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Ulrich Elling | ||||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| FirePlex Multiplexed Assay Technology – a Cell-line Profiling Tool | |||||
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Tue23 Mar02:25pm(15 mins)
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Zeev Gechtman | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Screening for functional transcriptional and splicing regulatory variants with GenIE | |||||
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Tue23 Mar03:00pm(20 mins)
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Dr Sarah Cooper | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| CRISPR/Cas9 - from functional genomics applications to therapeutic genome editing | |||||
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Tue23 Mar03:20pm(20 mins)
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Dr Lars Steinmetz | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| CRISPR Tools to Mitigate Attrition Rate Risk in Drug Development | |||||
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Tue23 Mar03:40pm(15 mins)
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Dr Kai Wilkens | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Accelerate functional genomics studies with simultaneous capture of CRISPR guides and gene expression profiles at single cell resolution. | |||||
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Tue23 Mar03:55pm(5 mins)
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Stephen Hague | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Ultra-high throughput single-cell RNA sequencing and perturbation screening by combinatorial fluidic indexing | |||||
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Tue23 Mar04:15pm(20 mins)
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Dr Paul Datlinger | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| A single-cell CRISPR screen in >100k primary human T cells | |||||
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Tue23 Mar04:35pm(5 mins)
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Dr Tilmann Buerckstuemmer | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Advanced iPSC technologies for neurodegenerative disease research | |||||
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Tue23 Mar04:40pm(20 mins)
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Michael Ward | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
| Joint Q&A Session | |||||
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Tue23 Mar05:00pm(20 mins)
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Michael Ward |
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Dr Lars Steinmetz | |
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Dr Sarah Cooper |
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Dr Paul Datlinger | ||
| Session : Functional Genomics | |||||
| Room: Conference Hall | |||||
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Tue23 Mar05:20pm(60 mins)
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Horizon Discovery Hot Topic Discussion - Understanding the paradigm of cellular visualization |
| Welcome & Introductions | |||||
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Wed24 Mar11:00am(5 mins)
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Dr Andrew Bassett |
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Dr Marcello Maresca | |
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Dr Klio Maratou | ||||
| Session : Welcome & Introductions | |||||
| Room: Conference Hall | |||||
| Examining intrinsic and extrinsic regulation of human brain development using cerebral organoids | |||||
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Wed24 Mar11:05am(45 mins)
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Dr Madeline Lancaster | ||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Highly efficient single-cell cloning of gene-edited human iPSCs in sub-microliter volumes | |||||
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Wed24 Mar11:50am(30 mins)
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Dr Katia Mattis | ||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Session Chair Welcome | |||||
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Wed24 Mar01:20pm(5 mins)
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Dr Klio Maratou | |||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Therapeutic strategies via genome engineering: new approaches and new challenges | |||||
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Wed24 Mar01:25pm(20 mins)
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Prashant Mali | |||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Deciphering the pathogenicity of cardiac disease-associated genetic variants using human iPSCs and gene editing | |||||
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Wed24 Mar01:45pm(20 mins)
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Dr Richard Davis | |||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| High-throughput detection of CRISPR/Cas 9 gene editing efficiency, cell proliferation, viability, and monoclonality validation using image cytometry | |||||
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Wed24 Mar02:05pm(15 mins)
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Dr Sun Yung | ||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Cell engineering at the speed of light | |||||
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Wed24 Mar02:30pm(20 mins)
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Dr Greg Sienski | |||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Joint Q&A Session | |||||
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Wed24 Mar02:50pm(20 mins)
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Prashant Mali |
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Dr Richard Davis | |
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Dr Greg Sienski | ||||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models | |||||
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Wed24 Mar03:10pm(15 mins)
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Kam Dhaliwal | ||
| Session : Target Validation - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Editing bone marrow stem cells to cure blood disorders | |||||
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Wed24 Mar03:35pm(45 mins)
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Prof Jacob Corn | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Mechanistic Insights into Cytosine and Adenine Base Editors | |||||
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Wed24 Mar04:20pm(20 mins)
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Prof Alexis Komor | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Expanding gene-editing tool delivery and targeting range in human cells | |||||
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Wed24 Mar04:45pm(20 mins)
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Manuel Goncalves | ||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Strategies to improve precision and safety of human cells manipulation | |||||
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Wed24 Mar05:05pm(20 mins)
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Dr Claudio Mussolino | ||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Joint Q&A Session | |||||
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Wed24 Mar05:25pm(20 mins)
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Prof Alexis Komor |
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Manuel Goncalves | |
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Dr Claudio Mussolino | ||||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Modulation of DNA repair pathways by HDR-CRISPR promotes seamless genome editing in primary human hematopoietic cells | |||||
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Wed24 Mar05:45pm(5 mins)
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Antonio Carusillo | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Modulation of DNA repair pathways by HDR-CRISPR promotes seamless genome editing in primary human hematopoietic cells | |||||
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Wed24 Mar05:45pm(5 mins)
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Antonio Carusillo | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Homology-directed safe harbour insertion of transgenes encoding full-length dystrophin through high-capacity adenoviral vector delivery of CRISPR-Cas9 nucleases and donor DNA | |||||
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Wed24 Mar05:50pm(5 mins)
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Francesca Tasca | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| What do people think about genetic engineering: a systematic review of post-CRISPR questionnaires | |||||
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Wed24 Mar05:55pm(5 mins)
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Mr Pedro Ramos | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Joint Q&A Session | |||||
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Wed24 Mar06:00pm(5 mins)
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Francesca Tasca |
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Antonio Carusillo | |
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Mr Pedro Ramos | ||||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
| Conference Close & Poster Winner Presentations | |||||
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Wed24 Mar06:05pm(10 mins)
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Dr Marcello Maresca | |||
| Session : Therapeutics - Sponsored by Iota Sciences | |||||
| Room: Conference Hall | |||||
