Translating Ideas into Therapies 2021- Co-hosted with the British Pharmacological Society

Posters

Osafo
Dr Newman Osafo
Kwame Nkrumah University of Science and Technology
Ghana
1Ref: PP018 Anti-ulcerative colitis potential of the hydroethanolic extract of the dried fruits of Xylopia aethiopica in rats
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Calle
Dr Yolanda Calle
University of Roehampton
2Therapeutic drugs promote differentiation of Acute Myeloid Leukaemia (AML) blasts into a migratory and chemo-resistant phenotype facilitated by the bone marrow microenvironment.
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ALROSAN
Mr Khaled ALROSAN
Keele university
3P006 Using nanoparticles to improve the therapeutic index of navitoclax for the treatment of ovarian cancer
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Swift
Dr Matthew Swift
University of Nottingham
4Ref: P008 Inhibition of SPRK1 in vivo in mice reduces nociceptive behaviour in a model of chemotherapeutic peripheral neuropathy.
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Hernández
Mr Álvaro Hernández
ZeClinics
Spain
5A zebrafish-based pipeline for in vivo quality control of new Cas9 variants
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Rankin
Dr Elly Rankin
Miltenyi Biotec
6Isolation of functional cells straight from buffy coat, LRSC, and Leukopak®
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Pasquini
Dr Miriam Pasquini
Exscientia
7Ref: P013 Unravelling the druggability of DNA helicases through enzyme kinetics and mathematical modelling
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Davies
Dr David Davies
Antabio
France
8Ref: P009 SAR Leading to the Discovery of ANT3310, a Novel DBO β-lactamase Inhibitor which Potentiates Meropenem Activity Against Carbapenemase-Resistant Acinetobacter baumannii (CRAB) and Enterobacteriaceae (CRE)
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MAHAPATRA
Dr CHITARANJAN MAHAPATRA
University of California San Francisco
United States
9Ref: P021 Computational Study of SARS-CoV-2 Infection Inhibitor Hydroxychloroquine on Cardiac Toxicity
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Andrade
Ms Stéphanie Andrade
Faculty of Engineering of University of Porto
Portugal
10Ref: P007 Interaction of Aβ peptide with vitamin B12: Implication for the therapy of Alzheimer’s disease
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Alhaidar
Ms Sara Alhaidar
King Saud University
Saudi Arabia
11Ref: P011 Role of G Protein-Coupled Receptor kinase 5 in Animal Model of Cardiac Hypertrophy
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Qaboli
Ms Samaher Qaboli
King Saud University
Saudi Arabia
12Ref: P012 Sitagliptin Mitigates Diabetic Nephropathy in a Rat Model of Streptozotocin-Induced Type 2 Diabetes: Possible Role of PTP1B/JAK-STAT Pathway
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Waterman-Smith
Mr Jon Waterman-Smith
Nilogen Oncosystems
United States
13Evaluating the effectiveness of ADC targeted therapy in a patient-derived ex vivo tumoroid model, 3D-EXplore, for quantitative tumor cell killing
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Patel
Ms Nikita Patel
QMUL
14Ref: P015 Inhibition of Bruton’s tyrosine kinase reduces organ injury and dysfunction in a rat model of severe haemorrhage
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KOSEMANI
Mr SAMSON KOSEMANI
The University of Ibadan
Nigeria
15Ref: P022 Fraction from Calliandra portoricensis Reduces 7,12- Dimethylbenz(a)Anthracene-Induced Mammary Tumors in Wistar Rats
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Al Matrafi
Mr Abdullah Al Matrafi
IAU
Saudi Arabia
16Ref: P016 Identifying and repurposing drugs capable of stabilizing multiple variants of the SARS-Cov-2 S-glycoprotein in a closed conformation, using in silico techniques
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Mohammad
Miss Shireen Mohammad
Barts and the London School of Medicine and Dentistry, Queen Mary University of London
17Ref: P010 A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice
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Martins Silva
Guilherme Martins Silva
University of São Paulo
Brazil
18Ref: P014 Development of Robust and Predictive Machine Learning QSAR Models for Hepatic Stability
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Southan
Dr Christopher Southan
TW2Informatics
Sweden
19Ref: P017 Chemical probe assessments for expanding the drug target envelope
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Pattyn
Mrs Sofie Pattyn
ImmunXperts
Belgium
20In vitro exhausted T cell assay for immuno-oncology candidates
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Messina
Ms Flavia Messina
University College Dublin
Ireland
21Ref: P002 Evaluation of the neuroprotective mechanism of 7,8-dihydroxyflavone and generation of corresponding sustained release nano/microparticles for improved ocular drug delivery
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Schloer
Dr Sebastian Schloer
University of Muenster
Germany
22P005 Targeting the endolysosomal host-SARS-CoV-2 interface by the FIASMA fluoxetine and the drug synergy of combinatory treatment with remdesivir
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