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Wed30 Jun09:00am(60 mins)
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WuXi AppTec Workshop - New technologies for target discovery and validation Abstract - library screen platform propelled by various new technologies, and extension to the challenging field of immunology, as well as expansion and utilization in multiple new modalities. • Advanced genetic manipulation platforms propelled by CRISPR and other new technologies • Gene editing in various human and mouse primary immune cells • From new tech to new modalities (PROTAC, TCR-T/CAR-T, AOC/ASO etc) Speakers - Baiqiu Wang, M.D.,Ph.D; Vice President of discovery biology, HDB-WuXi AppTec, Shelley (Fang) Zhang, M.D.,Ph.D, Director II, HDB-WuXi AppTec Moderator: Dave Madge, Ph.D; Vice President of Research Service Division, WuXi AppTec, |
| Keynote: Artios Pharma – targeting DNA repair vulnerabilities in cancer | |||||
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Wed30 Jun10:10am(50 mins)
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Dr Simon Boulton | ||
| Session : Keynote Speaker | |||||
| Room: Conference Room | |||||
| Session Chair Welcome | |||||
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Wed30 Jun11:10am(5 mins)
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Dr Michael Howell |
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Dr Sam Groom | |
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Using Genetics and Genomics to Drive Drug Discovery and Development | |||||
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Wed30 Jun11:15am(25 mins)
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Victor Neduva | |||
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Early identification of target candidates for pancreatic adenocarcinoma immunotherapy | |||||
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Wed30 Jun11:40am(30 mins)
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Dr Olaf Hardt |
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Dr Daniel Schäfer |
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Hit and Run: a rapid route to new target ID with PROTEINi | |||||
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Wed30 Jun12:10pm(25 mins)
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Dr Benedict Cross | ||
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Streamlining Collaboration and Development for Neglected Disease Drug Discovery Using CDD Vault | |||||
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Wed30 Jun12:35pm(15 mins)
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Kelly Bachovchin | ||
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
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Wed30 Jun12:50pm(30 mins)
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Miltenyi Biotec Miltenyi Hot Topic Workshop - • Issue re Tissues When the tissue is the issue: tips and tricks for successful single cell sequencing The reliability and quality of any genomic analysis starts with a proper preparation of the sample. This is particularly key in single-cell and single-nuclei sequencing, where working with highly viable single-cell suspensions, and intact single-nuclei is of utmost importance to ensure good quality data. In this session, we will guide you through our workflow solutions for optimal preparation of cells or nuclei prior to genomic analysis. Regardless of the type of cellular samples you work with, we provide gentle and automated techniques to get the most out of your samples for an increased quality and reliability of your genomic results. |
| Identification of novel therapeutics for fibrotic diseases using phenotypic screening | |||||
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Wed30 Jun02:30pm(20 mins)
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Prof Selim Cellek | |||
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Single-cell CRISPR screens in primary human T cells | |||||
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Wed30 Jun02:50pm(15 mins)
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Dr Tilmann Buerckstuemmer | ||
| Session : Target ID & Validation | |||||
| Room: Conference Room | |||||
| Routes to Funding Panel Discussion | |||||
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Wed30 Jun03:40pm(5 mins)
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Dr Ian Tomlinson | ||
| Session : Routes to Funding Session | |||||
| Room: Conference Room | |||||
| Perspectives on Grant Funding & Technology Transfer | |||||
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Wed30 Jun03:45pm(10 mins)
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Dr Paul Mercer | |||
| Session : Routes to Funding Session | |||||
| Room: Conference Room | |||||
| Perspectives on Venture Capital | |||||
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Wed30 Jun03:55pm(10 mins)
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Prof Helen Philippou | |||
| Session : Routes to Funding Session | |||||
| Room: Conference Room | |||||
| Perspectives on Consortia & Industry Collaboration | |||||
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Wed30 Jun04:05pm(10 mins)
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Dr Julie Brady | |||
| Session : Routes to Funding Session | |||||
| Room: Conference Room | |||||
| Perspectives on Novel Routes to Translation | |||||
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Wed30 Jun04:15pm(10 mins)
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Dr Nadine Clemo | |||
| Session : Routes to Funding Session | |||||
| Room: Conference Room | |||||
| Development of an Intracellular Quantitative Assay to Measure Compound Binding Kinetics | |||||
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Thu1 Jul09:10am(20 mins)
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Charles Lay | ||
| Session : Drugging your target | |||||
| Room: Conference Room | |||||
| Potential use of CRISPR in therapeutic applications | |||||
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Thu1 Jul10:00am(25 mins)
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Dr Pinar Akcakaya | |||
| Session : Drugging your target | |||||
| Room: Conference Room | |||||
| The challenges of a novel target portfolio | |||||
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Thu1 Jul10:45am(25 mins)
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Steve Rees | ||
| Session : Drugging your target | |||||
| Room: Conference Room | |||||
| Targeting KRAS via inhibition of the KRAS-SOS1 interaction | |||||
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Thu1 Jul11:10am(15 mins)
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Dr Roman Hillig | ||
| Session : Drugging your target | |||||
| Room: Conference Room | |||||
| Writing and erasing O-GlcNAc from target proteins in cells | |||||
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Thu1 Jul11:25am(25 mins)
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Dr Christina Woo | ||
| Session : Drugging your target | |||||
| Room: Conference Room | |||||
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Thu1 Jul12:15pm(30 mins)
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10x Genomics 10x Genomics Hot Topic Workshop Title Accelerate functional genomics studies with simultaneous capture of CRISPR guides and gene expression profiles at single cell resolution. Abstract: Pooled CRISPR screening is a powerful method for identifying genes involved in complex biological mechanisms such as cell proliferation, cell survival and drug/toxin resistance. The Chromium Single Cell Gene Expression Solution combined with Feature Barcode technology provides a high-throughput and scalable approach to assess the effects of perturbations on gene expression via direct capture of gRNAs and polyadentlyated mRNAs from the same single cell. This powerful solution allows analysis of regulatory gene networks and pathways involved in development and disease, resolve complex biological pathways and dissect cellular regulation at an unprecedented scale with single cell resolution. Speaker Details Stephen Hague, PhD. Senior Science and Technology Advisor, 10x Genomics. |
| Session Chair Welcome | |||||
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Thu1 Jul01:45pm(5 mins)
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Dr Simon Chell |
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Dr Ajay Gupta | |
| Session : Clinical Insights & Experimental Medicine | |||||
| Room: Conference Room | |||||
| Hepato-biliary organoids and applications in regenerative medicine | |||||
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Thu1 Jul01:50pm(25 mins)
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Dr Monique Verstegen | ||
| Session : Clinical Insights & Experimental Medicine | |||||
| Room: Conference Room | |||||
| The consequenses of inaccurate or inappropriate cell analysis for down-stream assays | |||||
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Thu1 Jul02:15pm(15 mins)
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Dr Suzanne Riches | ||
| Session : Clinical Insights & Experimental Medicine | |||||
| Room: Conference Room | |||||
| Leveraging genetic insight into potential drug targets for vascular disease | |||||
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Thu1 Jul02:30pm(25 mins)
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Dr Scott Damrauer | ||
| Session : Clinical Insights & Experimental Medicine | |||||
| Room: Conference Room | |||||
| The TRAIL less travelled: targeting the pro-tumourigenic role of TRAIL in cancer | |||||
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Thu1 Jul03:25pm(25 mins)
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Prof Henning Walczak | |||
| Session : Clinical Insights & Experimental Medicine | |||||
| Room: Conference Room | |||||
| Keynote: The Many Facets of Prostacyclin Mimetics: Therapeutic Applications in Cardiovascular Disease | |||||
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Thu1 Jul04:00pm(50 mins)
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Prof Lucie Clapp | ||
| Session : Keynote Speaker | |||||
| Room: Conference Room | |||||
